A road trip drive across the United States is more than just a vacation—it’s an adventure that offers breathtaking views, historic landmarks, and unforgettable memories. From the Pacific Coast to the heart of the South, America’s highways and byways hold some of the world’s most iconic driving experiences.
Whether you’re a solo traveler seeking solitude, a couple craving a romantic drive getaway, or a group of friends or family looking to create unforgettable memories, these five great American road trips offer something for everyone. From breathtaking scenic views and iconic landmarks to hidden gems tucked away off the beaten path, each route promises adventure and inspiration, along with practical tips to help you plan the ultimate journey of a lifetime.
1. Pacific Coast Highway (California State Route 1)
Route: San Francisco to San Diego
Distance: Approx. 600 miles
Best Time to Go: April to October
California’s Pacific Coast Highway is one of the most scenic drives in the world. With sweeping ocean views, coastal cliffs, and charming towns like Monterey and Santa Barbara, it’s a dream road trip for any traveler.
Must-See Stops:
- Big Sur for its rugged coastline
- Hearst Castle in San Simeon
- Malibu beaches near Los Angeles
Travel Tip: Drive southbound so you’re on the ocean side of the road, allowing better views and easier pull-offs for photos.
Related guide: Ultimate Pacific Coast Road Trip Planner
2. Route 66 – The Mother Road
Route: Chicago, Illinois to Santa Monica, California
Distance: Approx. 2,448 miles
Best Time to Go: May to September
Route 66 is a legendary highway that offers a nostalgic slice of Americana. It spans eight states and gives you the chance to explore quirky roadside attractions, old diners, and vintage motels.
Must-See Stops:
- Cadillac Ranch in Amarillo, Texas
- Blue Whale of Catoosa, Oklahoma
- Wigwam Motel in Holbrook, Arizona
Travel Tip: Plan your overnight stays in advance, especially in small towns where lodging fills up fast.
More on this trip: Route 66 Road Trip Bucket List
3. Blue Ridge Parkway (Virginia to North Carolina)
Route: Shenandoah National Park to Great Smoky Mountains
Distance: Approx. 469 miles
Best Time to Go: Mid-September to late October for fall colors
If you love the mountains, the Blue Ridge Parkway is a must. Known as “America’s Favorite Drive,” this route offers rolling hills, scenic overlooks, and abundant wildlife.
Must-See Stops:
- Mabry Mill (milepost 176.1)
- Linville Falls (milepost 316.4)
- Craggy Gardens (milepost 364.6)
Travel Tip: There are no gas stations along the parkway, so plan fuel stops in nearby towns.
Explore more: Blue Ridge Parkway Hiking & Scenic Stops
4. Great River Road (Mississippi River Trail)
Route: Lake Itasca, Minnesota to New Orleans, Louisiana
Distance: Approx. 3,000 miles
Best Time to Go: Spring or fall
Following the path of the Mississippi River, the Great River Road cuts through 10 states and offers a unique look at America’s river culture. From farmland and bluffs to vibrant cities and delta blues towns, it’s a trip through history.
Must-See Stops:
- St. Louis Gateway Arch
- Mark Twain’s hometown of Hannibal, Missouri
- Oak Alley Plantation in Louisiana
Travel Tip: Consider stopping at state welcome centers along the way for free maps and local travel advice.
Plan your journey: Great River Road Driving Tips
5. Overseas Highway (Florida Keys)
Route: Miami to Key West, Florida
Distance: Approx. 113 miles
Best Time to Go: December to May (dry season)
This tropical road trip stretches over 42 bridges and small islands between mainland Florida and Key West. The Overseas Highway is perfect for beach lovers and seafood fans.
Must-See Stops:
- Seven Mile Bridge
- Bahia Honda State Park
- Southernmost Point in Key West
Travel Tip: Leave early in the morning to avoid heavy traffic and enjoy peaceful ocean views.
Get details: Florida Keys Road Trip Travel Guide
Bonus Tips for Road Trip Travelers
Here are a few smart tips to make your road trip smooth and enjoyable:
- Plan your route, but stay flexible – Some of the best finds are unplanned.
- Download offline maps – Many scenic routes have limited cell service.
- Pack smart – Bring a cooler, first-aid kit, and charging cables.
- Check your vehicle – Ensure tires, brakes, and oil are road-ready.
- Book accommodations early in popular seasons.
Why Road Trips Are Making a Comeback
With rising airfares and the desire for freedom and open space, road trips have made a huge comeback in recent years. They offer the perfect blend of adventure, affordability, and personalized travel.
Whether you’re chasing ocean views on California’s coast or diving into the soul of America on Route 66, these five road trips showcase the best of what the U.S. has to offer. Every mile brings new scenery, new people, and new stories worth remembering.
So pack your bags, fuel up, and hit the road.
Related Reading:
- Top 10 Packing Essentials for Every Road Trip
- Budget Travel Tips for U.S. Road Adventures
- National Park Road Trip Planner
Also read – Discover the 3 Best National Parks in the USA Today
