The US tech industry is booming once again. From artificial intelligence to climate tech and health innovations, new startups are entering the scene with bold ideas and game-changing technologies. These startups are not only creating solutions but also attracting top investors and reshaping entire industries.
In this year-round tracking report, we bring you some of the most promising tech startups in the United States that are worth keeping an eye on in 2025. Whether you’re a tech enthusiast, investor, entrepreneur, or just curious about the future of innovation, these names deserve your attention.
Let’s dive into the top rising tech startups making waves in 2025.
- Perplexity AI – Redefining Search Engines
Founded: 2022
Based in: San Francisco, CA
Sector: AI / Search
Perplexity AI is on a mission to challenge traditional search engines like Google. It combines large language models with real-time web search, offering direct and reliable answers instead of just links. It’s like asking a knowledgeable friend instead of digging through dozens of search results.
With millions of users and rapid funding rounds, Perplexity is becoming a favorite among tech-savvy users and professionals looking for smarter ways to access information.
- Humane – Tech That Disappears into Life
Founded: 2018
Based in: San Francisco, CA
Sector: Consumer AI / Wearable Tech
Humane has launched one of the most talked-about gadgets of the year — the AI Pin. It’s a screenless wearable device powered by AI that lets you interact with technology in a more natural way, using voice and gestures.
Founded by former Apple designers, Humane aims to reduce screen time and integrate AI into daily life in a minimal, human-first way. The company has already raised over $200 million and is backed by big names like OpenAI’s Sam Altman.
- Rewind AI – Your Perfect Memory Assistant
Founded: 2022
Based in: San Francisco, CA
Sector: Productivity / AI
Imagine never forgetting a meeting, webpage, or conversation. That’s the promise of Rewind AI. The startup records everything you see, hear, or do on your device and uses AI to help you search and recall it instantly.
While privacy concerns are being debated, the company assures users that all data stays local and private. For professionals, students, and researchers, Rewind AI is becoming a must-have tool in a noisy digital world.
- Twelve – Making Jet Fuel from Air
Founded: 2015
Based in: Berkeley, CA
Sector: Climate Tech / Clean Energy
Twelve is one of the most fascinating startups in the climate tech space. They convert CO₂ into useful products like jet fuel, chemicals, and plastics — without using oil.
Their technology, called carbon transformation, could help reduce greenhouse gas emissions in hard-to-decarbonize industries. In 2025, they’ve expanded partnerships with airlines and government bodies, making Twelve a serious player in the clean energy revolution.
- Hippocratic AI – AI Nurses for Safer Healthcare
Founded: 2023
Based in: Palo Alto, CA
Sector: Health Tech / AI
Unlike other AI startups, Hippocratic AI focuses only on non-diagnostic healthcare support. Their goal? To create safe and empathetic AI nurses and health assistants that can assist in elder care, appointment reminders, medication education, and more.
Their models are trained on a strict “do no harm” principle, setting a new standard in ethical medical AI. With the U.S. facing a shortage of healthcare workers, Hippocratic AI could be a timely solution.
- Anduril Industries – Building the Future of Defense Tech
Founded: 2017
Based in: Costa Mesa, CA
Sector: Defense / AI / Robotics
Founded by Palmer Luckey, the creator of Oculus VR, Anduril is redefining defense technology. The company builds autonomous systems for border security, battlefield surveillance, and national defense.
With advanced AI, robotics, and drone systems, Anduril is already working with the U.S. Department of Defense. In a world of evolving threats, it’s one of the few startups directly shaping military tech with cutting-edge solutions.
- Tome – Presentations Powered by AI
Founded: 2020
Based in: San Francisco, CA
Sector: Productivity / AI
Tome is becoming the go-to tool for professionals who hate making slides. Just type your ideas, and Tome turns them into beautiful, visual presentations powered by AI.
With over 10 million users worldwide, this storytelling platform is used by students, marketers, founders, and sales teams alike. In a fast-moving world where ideas need to be shared quickly, Tome saves time without sacrificing creativity.
- Veed.io – Fast, Simple Video Editing Online
Founded: 2018
Based in: Remote (UK/USA presence)
Sector: Creator Economy / Video Tech
Although started in the UK, Veed.io has gained a strong presence in the US. It offers easy, browser-based video editing — no download needed. From YouTubers to business owners, it’s loved by those who want pro-level video tools without complex software.
With growing demand for content and AI-powered features like auto-subtitling and background removal, Veed.io is now competing with giants like Adobe.
What Makes These Startups Stand Out?
The US startup ecosystem is highly competitive, but the startups mentioned above are breaking through for a few key reasons:
Clear Problem Solving: Each startup addresses real-world problems, whether it’s healthcare staffing, climate change, or inefficient productivity tools.
Strong Leadership: Most of these startups are founded by ex-Google, Apple, or Facebook engineers and designers who know how to scale technology.
AI Integration: Almost all are leveraging artificial intelligence to build smarter, faster, and more personalized solutions.
Rapid Growth: These companies are growing fast, attracting talent and big investments — a sign of strong product-market fit.
The Startup Landscape in 2025: What’s Trending
Here are a few clear trends we’re noticing across the US startup scene in 2025:
AI for Real-Life Use: The focus has shifted from general AI chatbots to highly specific, useful AI products.
Sustainable Tech: Startups like Twelve are proving that green innovation is not just good for the planet, but also profitable.
Healthcare Innovation: With rising healthcare costs and staffing shortages, startups are now solving for better patient care using safe tech.
User-Centered Tools: From Tome to Rewind, companies are building tools that give users time back and make work simpler.
Conclusion: Keep Your Eyes on These Game Changers
The US remains a global powerhouse for tech innovation, and these startups are proof that the future is already being built — today. Whether you’re an investor, job seeker, or tech lover, tracking these startups throughout the year gives you a front-row seat to how technology is shaping the world around us.
Stay tuned. The next big thing could be launching from a small garage or a co-working space — right now.
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