When it comes to advanced healthcare and top-tier medical treatment in Southern California, Keck Hospital of USC stands out as a leader. Located in the heart of Los Angeles, CA, this academic medical center is part of the Keck Medicine of USC network and affiliated with the prestigious University of Southern California (USC). With a commitment to innovation, patient care, and cutting-edge research, Keck Hospital of USC has earned a reputation as one of the best hospitals in the country.
In this article, we’ll explore what makes Keck Hospital of USC unique, its history, specialties, services, and why it remains a top choice for patients seeking high-quality medical care in Los Angeles and beyond.
Overview of Keck Hospital of USC
Keck Hospital of USC is a 401-licensed-bed acute care hospital located in Los Angeles. It’s part of the Keck Medicine of USC health system, which also includes the USC Norris Cancer Hospital, USC Verdugo Hills Hospital, and more than 80 specialty clinics throughout Southern California.
The hospital is known for handling some of the most complex medical cases in the region. With highly trained staff, experienced physicians, and access to the latest medical technologies, Keck Hospital serves as a hub for excellence in medicine and surgery.
History and Background
Originally called USC University Hospital, the facility was renamed Keck Hospital of USC in 2011 after receiving a $150 million donation from the W.M. Keck Foundation. This generous contribution helped elevate the hospital’s capabilities and further integrated it with the university’s health sciences programs.
USC’s medical legacy spans more than a century. Keck Hospital continues to build on this legacy by combining academic excellence with outstanding clinical care.
World-Class Medical Specialties
One of the reasons Keck Hospital of USC is so highly regarded is because of its wide range of medical specialties and subspecialties, many of which are ranked among the top in the nation.
Here are some of the leading departments:
- Cardiology and Heart Surgery: Offers advanced heart transplants, valve repair, and electrophysiology.
- Neurology and Neurosurgery: Specializes in complex brain and spine surgeries, including epilepsy and tumor treatment.
- Oncology: Works closely with the USC Norris Comprehensive Cancer Center to offer personalized cancer care.
- Orthopedics: Known for joint replacement, sports medicine, and spinal surgeries.
- Transplant Services: Includes kidney, liver, lung, and heart transplants with excellent success rates.
- Urology and Nephrology: Offers specialized treatment for kidney disorders and urological cancers.
- Gastroenterology: Advanced care for digestive diseases, including IBD and liver disorders.
These departments are led by nationally recognized experts and supported by multidisciplinary teams that work together for better patient outcomes.
Technology and Innovation
Keck Hospital of USC continues to invest in state-of-the-art medical technology, helping provide faster and more accurate diagnoses and effective treatment.
Advanced tools and systems used at Keck Hospital include:
- Robotic-assisted surgery with the Da Vinci Surgical System
- Intraoperative MRI and CT scanning for better precision
- PET/CT imaging for cancer diagnosis and monitoring
- Minimally invasive surgical suites for shorter recovery times
- Artificial intelligence tools to assist in diagnostics and treatment planning
These technologies allow doctors to perform complex procedures with greater accuracy and improved results for patients.
USC Faculty Physicians – Experts in Their Fields

All physicians at Keck Hospital of USC are also faculty members at the Keck School of Medicine of USC. This connection ensures that patients receive care from doctors who are involved in research, education, and continuous medical development.
Patients benefit from:
- Access to the latest clinical trials and experimental therapies
- A team-based approach for second opinions and complex care
- Evidence-based treatments informed by ongoing medical research
This academic and clinical integration enhances the quality of care and gives patients access to the most advanced treatment options available.
Patient-Centered Approach
Keck Hospital of USC places a strong emphasis on providing personalized and compassionate care to every patient. The hospital focuses on comfort, clarity, and support at every stage of treatment.
Key aspects of the patient experience include:
- Individualized treatment plans based on patient needs
- Dedicated care coordinators and nurse navigators
- Multilingual staff and interpretation services
- Modern private rooms with high comfort and amenities
- Digital tools like MyUSCChart for managing appointments, prescriptions, and virtual visits
The hospital’s approach ensures patients feel heard, supported, and well-cared-for throughout their journey.
Accreditations and National Rankings
Keck Hospital of USC consistently earns high national rankings for its medical services and specialties.
Some recent highlights include:
- Ranked among the Top 20 hospitals in the U.S. by U.S. News & World Report (2024)
- 11 nationally ranked specialties including cancer, cardiology, and neurology
- Magnet Recognition from the American Nurses Credentialing Center for nursing excellence
- Accredited by The Joint Commission for high-quality standards in patient care
- Certified as a Comprehensive Stroke Center
These recognitions highlight the hospital’s commitment to safety, excellence, and innovation in healthcare.
Location and Facilities
Keck Hospital of USC is located at:
1500 San Pablo Street, Los Angeles, CA 90033
Just east of downtown Los Angeles, the hospital is easily accessible by major highways and public transit. The hospital campus is modern and designed with patient comfort and convenience in mind.
On-site features include:
- Private inpatient rooms with scenic views
- Specialized intensive care units (cardiac, surgical, and neuro)
- Rehabilitation and physical therapy centers
- Outpatient surgery centers
- Cafeterias and patient lounges
- On-campus parking and valet services
The entire layout of the hospital is focused on making the patient experience as comfortable and efficient as possible.
Education and Research at Keck Hospital
As part of the University of Southern California, Keck Hospital is deeply involved in medical education and research. The hospital works closely with the Keck School of Medicine to train the next generation of doctors and develop new treatments for challenging diseases.
Research areas include:
- Cancer therapies and immunotherapy
- Neurological disease treatment and prevention
- Stem cell therapy and regenerative medicine
- Genetic research and personalized medicine
- Infectious disease and vaccine development
Keck Hospital’s active role in research ensures patients have early access to groundbreaking treatments and clinical trials that may not be available elsewhere.
Why Patients Choose Keck Hospital of USC
Patients from across California, the U.S., and even internationally choose Keck Hospital of USC for several compelling reasons:
- Nationally ranked specialists and subspecialists
- State-of-the-art technology and equipment
- A supportive and personalized patient experience
- High success rates for complex procedures and surgeries
- Integrated academic, research, and clinical care
- Comprehensive insurance acceptance, including Medicare and Medi-Cal
Whether patients are dealing with a life-threatening illness, seeking a second opinion, or simply looking for top-quality care, Keck Hospital of USC offers a trusted and respected healthcare destination.
Final Thoughts
Keck Hospital of USC in Los Angeles, CA, is more than just a hospital. It’s a place where innovation meets compassion, where cutting-edge science and research are used to deliver exceptional medical care. With a team of top doctors, modern technology, and a strong academic foundation, Keck Hospital continues to set the standard for excellence in healthcare.
For anyone seeking high-quality medical treatment in Southern California, Keck Hospital of USC stands as a top choice. Whether you’re facing a challenging diagnosis or simply want the best care available, this hospital delivers expertise, support, and hope.
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